Endocrine Abstracts

Introduction: The natural history of adipsic diabetes insipidus (ADI) is not completely understood. Isolated case reports suggest occasional recovery of adipsia. We present the follow up of a cohort of 12 patients with ADI.Setting: National pituitary unit with interest in diabetes insipidus.Methods: ADI was identified by demonstrating absent thirst and AVP responses to hypertonic saline infusion. Results 12 patients with ADI were i...

Objective: Hypothyroidism is common and predominantly managed in primary care. Symptoms are non-specific, with thyroid function tests (TFT) required for diagnosis. We sought to investigate current practice in levothyroxine prescribing in primary care.Methods: We studied the initiation of levothyroxine using the General Practice Research Database (GPRD), the world’s largest database of anonymised medical records. Individuals with i) thyroid cancer ii...

Introduction: The average life expectancy and the prevalence of diabetes are increasing. Among the elderly population, type 2 diabetes is a growing problem, with a large proportion of newly diagnosed diabetics. Treating elderly diabetes can present unique challenges. Impaired cognitive and physical functioning among some elderly patients can make adjusting to a diabetes care routine more difficult and thus, contribute to the complexity of managing diabetes.<p class="abstex...

Introduction: Thyroid dysfunctions are relatively common presentations in Endocrine Practice. They are second to diabetes mellitus (DM) among endocrine disorders. However, management often involves the endocrinologists and surgeons.Aims: The aim of this review is to determine the spectrum of thyroid disorders and the pattern of presentation seen in our hospital.Method: It is a five (5) years study (June 2004–April 2009) that l...

FPLD is a rare monogenic cause of insulin resistance. We document responses to treatment with metformin in 2 adolescent sisters with FPLD due to heterozygosity for R482W LMNA gene mutation.The probands, aged 14 and 16 years, presented with secondary amenorrhoea, hirsutism and progressive acanthosis nigricans. Phenotypically they showed central obesity, nuchal enlargement, and thin muscular arms. These changes occurred post-pubertally. Anthrpometri...

Accelerated medial calcification is a major cause of premature cardiovascular mortality in people with chronic kidney disease. Evidence suggests that the concentration of extracellular Ca2+ and vascular smooth muscle cells play a pivotal role in the pathogenesis of vascular calcification. Extracellular Ca2+ is detected by the calcium-sensing receptor (CaSR). The CaSR is a G protein-coupled receptor that is expressed in a range of tissues, but characteriza...

Introduction: Klinefelter syndrome is the commonest sex chromosomal disorder in which the normal male karyotype 46XY, has at least one extra X chromosome. The commonest form is the 47XXY aneuploidy. It is characterized by hypergonatrophic hypogonadism, and associated with infertility and cardio-metabolic abnormalities. We report a case of a 36year old man who presented in our Endocrinology clinic in Ngeria.Case Presentation:</str...

Background: T2DM has been described as a complex mix bag of insulin resistance and β-cell defects in varying proportions. Several works have described in quantitative terms insulin resistance among diabetics and its relationship with proteinuria, the relative contribution of β- cell dysfunction have largely been extrapolated. This work is an attempt to provide the missing link in our clime.Objectives: The study aims to describe, in quantitative...

Background: Adrenal insufficiency remains a potentially life-threatening condition, necessitating adequate glucocorticoid replacement and appropriate stress-related adjustment to avoid crisis. Flu-like illness is a key precipitant of adrenal crisis. While some authorities recommend annual influenza vaccination for such patients, uptake rates in this population are unknown. Additionally, while seasonal vaccines may lead to minor symptoms in the general population, there are no ...

Acute hyponatraemia is a medical emergency with high mortality. Recent expert guidelines advocate treatment with intravenous boluses of 3% saline with the aim to reduce cerebral oedema more rapidly than traditional slow intravenous infusion, but there is a poor evidence base for this policy change. We retrospectively audited treatment of symptomatic hyponatraemia due to SIAD (n=57, age 22–76 year), comparing low dose (20 ml/h) and bolus infusion of 3% saline. Bol...